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網(wǎng)校開(kāi)發(fā)及擁有的課件范圍涉及公務(wù)員、財(cái)會(huì)類(lèi)、外語(yǔ)類(lèi)、外貿(mào)類(lèi)、學(xué)歷類(lèi)、

職業(yè)資格類(lèi)、計(jì)算機(jī)類(lèi)、建筑工程類(lèi)、等9大類(lèi)考試的在線網(wǎng)絡(luò)培訓(xùn)輔導(dǎo)。

上海科技大學(xué)是一所高水平、國(guó)際化的研究型大學(xué)。上海科技大學(xué)iHuman 研究所由一批包括諾貝爾獎(jiǎng)得主在內(nèi)的國(guó)際知名學(xué)者按照國(guó)際頂級(jí)研究所標(biāo)準(zhǔn)建設(shè)而成。iHuman研究所聚焦與人類(lèi)重大疾病相關(guān)的G蛋白偶聯(lián)受體（GPCR）及其相關(guān)的人體細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)研究領(lǐng)域，通過(guò)與國(guó)際知名學(xué)術(shù)研究機(jī)構(gòu)和大型藥物研發(fā)企業(yè)結(jié)成緊密的戰(zhàn)略聯(lián)盟，開(kāi)展產(chǎn)學(xué)研一體化的高水平研究。

上海科技大學(xué)iHuman研究所趙素文課題組使用計(jì)算生物學(xué)的方法，與iHuman各實(shí)驗(yàn)研究組密切合作，致力于研究以下課題：1．生物大分子結(jié)構(gòu)模擬：GPCR、人體細(xì)胞信號(hào)通路中的蛋白質(zhì)復(fù)合體的結(jié)構(gòu)模擬；2．配體發(fā)現(xiàn)：GPCR配體預(yù)測(cè)、GPCR藥物設(shè)計(jì)方法的開(kāi)發(fā)和應(yīng)用。現(xiàn)誠(chéng)招博士后1名。

一、招聘條件

1）計(jì)算生物學(xué)或計(jì)算化學(xué)背景相關(guān)專(zhuān)業(yè)博士畢業(yè)；優(yōu)先考慮在國(guó)際刊物上以第一作者或通訊作者發(fā)表過(guò)論文的申請(qǐng)者；

2）理解物理化學(xué)、統(tǒng)計(jì)熱力學(xué)原理；

3）有蛋白質(zhì)分子模擬/分子對(duì)接/分子動(dòng)力學(xué)模擬經(jīng)驗(yàn)者優(yōu)先考慮；

4）熟悉Linux操作，至少熟練使用一種腳本語(yǔ)言（Perl,Python等）；

5）具備極強(qiáng)的獨(dú)立科研能力、進(jìn)取心和優(yōu)良的團(tuán)隊(duì)精神；

6）具有良好的英語(yǔ)讀寫(xiě)和交流能力。

二、工作條件與工資待遇

按照上海科技大學(xué)相應(yīng)崗位的相關(guān)規(guī)定執(zhí)行，根據(jù)個(gè)人具體情況，提供具有競(jìng)爭(zhēng)力的薪酬、津貼和福利。本實(shí)驗(yàn)室會(huì)非常重視科研人員的職業(yè)發(fā)展，會(huì)提供各種科學(xué)培訓(xùn)和參加學(xué)術(shù)會(huì)議活動(dòng)的機(jī)會(huì)。

三、申請(qǐng)方式

1）詳細(xì)的個(gè)人中英文簡(jiǎn)歷：包括學(xué)習(xí)工作經(jīng)歷、主要研究工作內(nèi)容、代表論文論著、獲獎(jiǎng)情況。

2）三封推薦信。

3）所有材料用電子版發(fā)至iHuman@shanghaitech.edu.cn , 抄送至zhaosw@shaghaitech.edu.cn , 郵件標(biāo)題請(qǐng)注明：申請(qǐng)博士后-趙素文課題組-申請(qǐng)人姓名。

欲了解趙素文博士過(guò)去的研究工作，請(qǐng)參看：

[1] S. Zhao, R. Kumar, A. Sakai, M. W. Vetting, B. M. Wood, S. Brown, J. B. Bonanno, B. S. Hillerich, R. D. Seidel, P. C. Babbitt, S. C. Almo, J. V. Sweedler, J. A. Gerlt, J. E. Cronan, and M. P. Jacobson, “Discovery of new enzymes and metabolic pathways by using structure and genome context”, Nature, 502, 698-702 (2013)

[2] S. Zhao, A. Sakai, X. Zhang, M. W. Vetting, R. Kumar, B. Hillerich, B. San Francisco, J. Solbiati, A. Steves, S. Brown, E. Akiva, A. Barber, R. D. Seidel, P. C. Babbitt, S. C. Almo, J. A. Gerlt and M. P. Jacobson, “Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks”, eLife, e03275 (2014)

[3] M. P. Jacobson, C. Kalyanaraman, S. Zhao and B. Tian, “Leveraging structure for enzyme function prediction: methods, opportunities, and challenges”, Trends Biochem. Sci. 39 (8), 363-371 (2014)

[4] R. Kumar, S. Zhao, A. Sakai, M. W. Vetting, B. M. Wood, S. C. Almo, J. V. Sweedler, J. A. Gerlt, J. E. Cronan, and M. P. Jacobson, “Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant, proline betaine”, mBio, 5, (2014).

[5] B. Tian, F. Wallrapp, C. Kalyanaraman, S. Zhao, L. A. Eriksson, M. P. Jacobson, “Exploring enzyme substrate specificity with docking and QM/MM methods: A benchmarking study on the stereo-specificity of D-glucarate dehydratase”, Biochemistry, 52, 5511-5513 (2013).

[6] E. B. Miller, C. S. Murrett, K. Zhu, S. Zhao, D. A. Goldfeld, J. H. Bylund, and R. A. Friesner, “Prediction of long loops with embedded secondary structure using the Protein Local Optimization Program”, J. Chem. Theory Comput., 9, 1846-1864 (2013).

[7] S. Zhao, K. Zhu, J. Li, R. A. Friesner, “Progress in super long loop prediction”, Proteins, 79, 2920-2935 (2011).

[8] J. Li, R. Abel, K. Zhu, Y. Cao, S. Zhao, R. A. Friesner, “The VSGB 2.0 model: A next generation energy model for high resolution protein structure modeling”, Proteins, 79, 2794-2812 (2011).

[9] B. Sellers, K. Zhu, S. Zhao, R. A. Friesner, M. P. Jacobson, “Towards better refinement of comparative models: Predicting loops in inexact environments”, Proteins, 72, 959-971 (2008).

[10] K. Zhu, D. L. Pincus, S. Zhao, R. A. Friesner, “Long loop prediction using the Protein Local Optimization Program”, Proteins, 65, 438-452 (2006).

[11] X. Li, M. P. Jacobson, K. Zhu, S. Zhao, R. A. Friesner, “Assignment of polar states for protein amino acid residues using an interaction cluster decomposition algorithm and its application to high resolution protein structure modeling”, Proteins, 66 , 824-837 (2006).

[12] S. Zhao, L. Liu, Y. Fu, Q. Guo, “Assessment of the metabolic stability of the methyl groups in heterocyclic compounds using C-H bond dissociation energies: Effects of diverse aromatic groups on the stability of methyl radicals”, J. Phys. Org. Chem., 18, 353-367 (2005).

[13] Y. Feng, S. Zhao, L. Liu, J. Wang, X. Li, Q. Guo, “Blue-shifted dihydrogen bonds”, J. Phys. Org. Chem., 17, 1099-1106 (2004).

[14] Y. Feng, L. Liu, S. Zhao, J. Wang, Q. Guo, “Origin of conformational restriction in complexes of formyl compounds with boron Lewis acids and their related systems”, J. Phys. Chem. A, 108, 9196–9204 (2004).

[15] Y. Feng, L. Liu, J. Wang, S. Zhao, Q. Guo, “Homolytic C-H and N-H bond dissociation energies of strained organic compounds”, Journal of Organic Chemistry, 69, 3129-3138 (2004).

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